Overview
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial genome — one of the few peptides known to originate from mitochondrial DNA. It functions as a metabolic regulator across multiple tissues and declines with age, making it a key target in longevity research.
Mechanism of action
MOTS-c activates AMPK (the cell's energy sensor), enhancing glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. It also translocates to the nucleus under metabolic stress, regulating adaptive gene expression.
Reported benefits
- Improved insulin sensitivity and glucose tolerance
- Enhanced mitochondrial function and ATP production
- Increased exercise capacity and endurance
- Reduced visceral fat accumulation
- Potential lifespan extension in animal models
Research dosing
Research protocols typically use 10 mg subcutaneously 2–3 times per week. 6–8 week cycles.
Considerations
One of the most promising longevity peptides currently studied. Effects on metabolic markers (HbA1c, fasting glucose) are most pronounced in subjects with baseline metabolic dysfunction.
Research use only. This article is provided for educational purposes and is not medical advice. Products sold on this website are for laboratory research only and are not intended for human consumption. Not evaluated by the FDA.
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