Overview
This combination pairs the GHRH analog CJC-1295 (without DAC) with the selective ghrelin mimetic Ipamorelin. Together they produce a synergistic, short-duration GH pulse that closely mimics the body's natural release pattern — without elevating cortisol or prolactin.
Mechanism of action
CJC-1295 stimulates the GHRH receptor while Ipamorelin activates the ghrelin/GHS receptor. The two pathways converge in the anterior pituitary to amplify GH release synergistically — producing a stronger pulse than either peptide alone.
Reported benefits
- Natural pulsatile growth hormone release
- Improved sleep architecture and recovery
- Lean muscle preservation during cutting phases
- Skin, hair, and nail quality improvements
- No appreciable cortisol or prolactin elevation
Research dosing
Research protocols commonly use 100–300 mcg of each, injected subcutaneously 1–3 times daily — often pre-bed and post-workout. 8–12 week cycles.
Considerations
Best taken on an empty stomach (90 min after eating, 30 min before) since elevated insulin and free fatty acids blunt the GH pulse. Most physiologic GH-axis option available in research.
Research use only. This article is provided for educational purposes and is not medical advice. Products sold on this website are for laboratory research only and are not intended for human consumption. Not evaluated by the FDA.
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