Overview
Ipamorelin is a selective growth-hormone secretagogue. Among the GH-axis peptides, it is considered the cleanest — producing strong GH pulses without elevating cortisol, prolactin, ACTH, or aldosterone the way earlier secretagogues did.
Mechanism of action
Ipamorelin binds the GHS-R1a (ghrelin) receptor in the anterior pituitary, triggering pulsatile GH release. Its high selectivity for this receptor — without affecting others in the same family — is what gives it such a clean side-effect profile.
Reported benefits
- Strong, pulsatile GH release without side hormones
- Improved sleep quality and recovery
- Lean tissue support and fat metabolism
- Skin and connective tissue benefits
- Minimal appetite stimulation (unlike GHRP-6)
Research dosing
Research protocols use 100–300 mcg subcutaneously 1–3 times daily, ideally on an empty stomach. Often combined with a GHRH like CJC-1295 (no DAC).
Considerations
Cleanest GH secretagogue in the literature. Excellent entry point for GH-axis research with minimal side-effect risk. Best stacked with a GHRH for amplified pulses.
Research use only. This article is provided for educational purposes and is not medical advice. Products sold on this website are for laboratory research only and are not intended for human consumption. Not evaluated by the FDA.
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