Overview
Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone (α-MSH). It is studied primarily for its non-UV-mediated stimulation of melanin production (tanning) and for its pronounced effects on sexual function via central melanocortin pathways.
Mechanism of action
MT-2 binds non-selectively to melanocortin receptors MC1R, MC3R, MC4R, and MC5R. MC1R activation stimulates eumelanin production in melanocytes. MC4R activation in the CNS drives libido and erectile response. MC3R/4R also suppress appetite.
Reported benefits
- Accelerated tanning with reduced UV exposure
- Increased libido and sexual response
- Mild appetite suppression
- More uniform pigmentation
Research dosing
Research protocols: 250–500 mcg daily until desired pigmentation, then 2–3x weekly maintenance. Pre-titration with very low doses (100 mcg) is standard to assess tolerance.
Considerations
Nausea and facial flushing are common on first dose and resolve with titration. Existing moles may darken — baseline skin checks are recommended in research settings.
Research use only. This article is provided for educational purposes and is not medical advice. Products sold on this website are for laboratory research only and are not intended for human consumption. Not evaluated by the FDA.
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